Which medications for alcohol use disorder (AUD) have been studied in adolescents?

Naltrexone and disulfiram are two medications that have been studied in adolescents for the treatment of Alcohol Use Disorder (AUD). Naltrexone is an opioid receptor antagonist that helps reduce cravings and the rewarding effects of alcohol, making it an effective treatment option. Studies have shown that it is beneficial in decreasing alcohol consumption and preventing relapse in adolescent populations, as well as in adults.

Disulfiram, on the other hand, is a deterrent that works by causing unpleasant reactions when alcohol is consumed, thus discouraging drinking. Research has indicated its utility among adolescents, similar to how it is prescribed to adults, although the emphasis is often placed on proper adherence and supervision in younger patients.

Both medications have undergone investigation to evaluate their efficacy and safety in adolescents, making this combination a key answer regarding pharmacological options for treating AUD in younger individuals.

The other medications mentioned in the other choices, like acamprosate and bupropion, may have some evidence supporting their use in adults, but studies specifically targeting their use in adolescents with AUD are limited or lacking, making them less relevant to this context.