What can develop rapidly with the repeated use of hallucinogens?

Rapid development of tolerance is a well-documented phenomenon associated with the repeated use of hallucinogens. Tolerance occurs when an individual requires increasingly larger doses of a substance to achieve the same psychoactive effects that were once produced by smaller amounts. This adaptation can happen relatively quickly with certain hallucinogenic substances, meaning that users often find they need to consume more in order to experience the desired effects.

Hallucinogens, such as LSD or psilocybin, primarily affect serotonin receptors in the brain. With frequent exposure, the receptors can become less responsive to the substance, leading to a diminished effect unless greater doses are taken. This rapid tolerance is particularly notable in the context of hallucinogens as they do not generally produce physical dependence or withdrawal symptoms like many other substances do.

While dependency and withdrawal syndrome are typically associated with substances that have addictive properties and lead to physiological changes in the body, hallucinogens do not usually fit this profile. Allergic reactions, though possible, are not a common or expected response to hallucinogen use. Therefore, tolerance stands out as the primary concern that develops quickly with repeated use of these substances.