Which receptor does Delta 9 THC partially activate?

Delta 9 THC, or tetrahydrocannabinol, primarily exerts its effects by partially activating the CB1 receptor, which is predominantly found in the central nervous system. This receptor is integral to the psychoactive effects associated with cannabis use, as it influences various neurological processes, such as pain perception, mood regulation, and memory.

While Delta 9 THC does interact with the CB2 receptor, which is primarily located in the peripheral nervous system and immune tissues, its affinity and the level of activation at CB2 are significantly lower compared to its interaction with CB1. This selective activation of the CB1 receptor helps explain the highs associated with cannabis consumption and the psychoactive experiences reported by users.

Understanding the function and location of these receptors provides critical insight into the pharmacological action of cannabinoids and how they can be manipulated for therapeutic purposes, especially in treating conditions related to pain and mental health.