Which of the following is a major side effect of disulfiram?

Disulfiram is primarily used as a deterrent for alcohol consumption in individuals with alcohol use disorder. Its major side effect, which can include fatigue, is significant because it may be indicative of the medication's mechanism of action and impact on the body. Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, leading to an accumulation of acetaldehyde when alcohol is consumed. This reaction causes unpleasant symptoms that discourage further alcohol use.

Fatigue can occur as the body metabolizes acetaldehyde and can be exacerbated if alcohol is ingested. This symptom might reflect the body's stress response to the disulfiram-alcohol interaction as well as the impact of the medication on overall metabolism.

While weight gain, dry mouth, and euphoria could potentially occur with other medications, they are not major side effects associated with disulfiram. Therefore, fatigue is recognized among the more commonly reported side effects and highlights the importance of monitoring patients for this and other effects while on disulfiram therapy. Understanding these side effects helps healthcare providers to better manage the treatment and address issues that may arise for individuals taking disulfiram as part of their recovery from alcohol dependence.