Which mental disorder is most commonly associated with Substance Use Disorder?

Substance Use Disorder is frequently comorbid with Major Depressive Disorder (MDD). This relationship can be attributed to several factors. Firstly, individuals with MDD might use substances as a form of self-medication to alleviate their depressive symptoms, leading to a cycle of dependency and worsening mental health issues.

Furthermore, the symptoms of depression, such as low energy, anhedonia, and difficulty concentrating, can make it challenging for individuals to engage in preventive behaviors regarding substance use, thus increasing the likelihood of developing a Substance Use Disorder. Studies have consistently shown that individuals with MDD are at a higher risk of substance use and vice versa, suggesting a significant overlap in their pathways and the biological mechanisms involved.

In contrast, while anxiety disorders, personality disorders, and schizophrenia can also be associated with Substance Use Disorders, the prevalence and interplay between MDD and substance use are particularly notable in clinical settings. Therefore, Major Depressive Disorder is recognized as the mental disorder most commonly associated with Substance Use Disorder.