Which mental disorder has the least strong association with Substance Use Disorder?

Obsessive-Compulsive Disorder (OCD) has the least strong association with Substance Use Disorder when compared to the other options listed. This is because the underlying mechanisms and etiologies differ significantly between OCD and Substance Use Disorders.

OCD is characterized by intrusive thoughts and repetitive behaviors or mental acts performed to reduce anxiety. The compulsions in OCD do not typically drive substance use, and individuals with this disorder often aim to manage their anxiety rather than seek out substances for pleasure or relief. In contrast, conditions like Bipolar Disorder and PTSD are frequently associated with substance misuse, where individuals may use substances as a form of self-medication to cope with their symptoms. Bipolar Disorder can lead to impulsivity during manic episodes, often resulting in increased substance use, while PTSD may cause individuals to use substances to numb traumatic memories or anxiety. Generalized Anxiety Disorder can also lead to a higher likelihood of substance use as individuals may seek temporary relief from their persistent anxiety through alcohol or drugs.

Therefore, due to the distinct nature of OCD and its more limited association with substance use compared to the others, it stands out as having the least strong connection to Substance Use Disorder.