What neurotransmitter receptor do hallucinogens primarily target?

Hallucinogens primarily target the 5-HT receptor, specifically the serotonin receptors in the brain, such as the 5-HT2A receptor. These receptors are part of the serotonergic system and play a significant role in mood, perception, and cognition. When hallucinogens like LSD or psilocybin bind to these receptors, they can alter an individual's sensory experiences, thoughts, and emotions, leading to the characteristic hallucinatory effects associated with these substances.

The interaction of hallucinogens with the 5-HT receptors is believed to disrupt normal serotonin signaling and influence various neural pathways involved in perception and consciousness. This is why understanding the role of serotonin receptors is vital in addiction medicine and the study of psychoactive substances.