True or False: A person with a reduced function variant of CYP2A6 is likely to smoke more cigarettes.

A person with a reduced function variant of CYP2A6 is likely to smoke fewer cigarettes rather than more. This variant affects the metabolism of nicotine; individuals with a reduced function version of this enzyme metabolize nicotine more slowly. As a result, nicotine remains in their system for a longer period, leading to increased sensitivity to its effects. Therefore, they may not feel the need to smoke as often to achieve the desired effects, resulting in lower overall cigarette consumption.

The relationship between CYP2A6 function and smoking behavior is well-studied, revealing that those with a reduced function variant often have higher levels of nicotine available due to slower metabolism, which tends to reduce their smoking frequency. Consequently, they may find that they can satisfy their nicotine cravings with fewer cigarettes. This understanding aligns with findings from genetic studies on smoking behavior and nicotine dependence.